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Metformin Therapy and Breast Cancer Incidence in the Ha'il Region
Mhdia Osman1, Taif Muqbel2, Ahad Abduallh2
1Department of Clinical Pharmacy, Faculty of Pharmacy, University of Ha'il, P.O. Box 2440, Ha'il 55476, Saudi Arabia.
Background:
Metformin is a drug used to treat patients with type 2 diabetes, especially those who suffer from obesity. It is also used in the treatment of women with polycystic ovary syndrome (PCOS). This disease is related to insulin resistance and multiplied blood sugar ranges. Furthermore, it has been established that the use of metformin improves the menstrual cycles and ovulation rates of these women.
Methods:
A structured questionnaire was conducted to determine the prevalence of breast cancer among women using metformin in the Ha'il region.
Result:
The incidence of breast cancer among women using metformin in the Ha'il region is very low. Thus, it can be said that breast cancer cases declined among diabetics taking metformin. This means that metformin use is associated with a lower risk of breast cancer in women with type 2 diabetes, even in cases where these women have a family history of breast cancer.
Conclusions:
According to previous findings, metformin has been linked to lower breast cancer risk in women with type 2 diabetes. Furthermore, the findings of this study corroborate the literature on this subject by indicating that there is a substantial connection between metformin use and a lower risk of breast cancer in women with type 2 diabetes. However, further in vitro and in vivo experiments are crucial to investigate the protective effect of metformin against breast cancer and to confirm our findings.
