Related Experiment Video
Updated: Aug 10, 2025
06:04
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
Published on: September 27, 2024
998
The Hypertriglyceridemic Waist Phenotype Is Associated with Several Cardiovascular Risk Factors in Women with
Guadalupe Mendoza-Vázquez1,2, Sandra Guzmán-Silahua1,3, Jorge I Gamez-Nava4,5
1Unidad de Investigación Epidemiológica y en Servicios de Salud, Centro Médico Nacional de Occidente, Organo de Operacion Administrativa Desconcentrada, Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico.
Healthcare (Basel, Switzerland)
|February 11, 2023
Summary
The hypertriglyceridemic waist phenotype (HTWP) is common in rheumatoid arthritis (RA) patients, indicating increased cardiovascular risk factors (CVRF). This phenotype is linked to higher rates of hypertension, diabetes, and obesity in RA.
Area of Science:
- Rheumatology and Endocrinology
- Cardiovascular Health and Disease
Background:
- Rheumatoid arthritis (RA) is associated with cardiovascular risk factors (CVRF), including dyslipidemias and systemic inflammation.
- Cardiovascular disease (CVD) is a leading cause of mortality in RA patients.
- The hypertriglyceridemic waist phenotype (HTWP) identifies individuals with increased CVRF, but its prevalence and association with CVRF in RA are not well-established.
Purpose of the Study:
- To investigate the association between the hypertriglyceridemic waist phenotype (HTWP) and cardiovascular risk factors (CVRF) in women with rheumatoid arthritis (RA).
Main Methods:
- A cross-sectional study included 125 women diagnosed with RA.
- Measurements included anthropometry, bioimpedance, body mass index (BMI), disease activity score (DAS28), and health assessment questionnaire disability index (HAQ-Di).
- Lipid profiles were analyzed, calculating the atherogenic index (AI) and Framingham Risk Score. HTWP was defined as waist circumference ≥88 cm and triglycerides ≥150 mg/dL.
Main Results:
- HTWP was identified in 30.4% of the RA patients.
- Patients with HTWP exhibited a higher prevalence of arterial hypertension (AHT), Type 2 Diabetes Mellitus (DM), elevated BMI, increased fat mass, and higher atherogenic index (AI).
- HTWP was significantly associated with the presence of metabolic syndrome (MetS) and overall cardiovascular risk (CVR).
Conclusions:
- The hypertriglyceridemic waist phenotype (HTWP) is prevalent in rheumatoid arthritis (RA) and is associated with multiple cardiovascular risk factors (CVRF).
- Further longitudinal studies are warranted to explore the predictive value of HTWP for cardiovascular events in RA patients.
Related Concept Videos
01:29Cholesterol: Significance and Regulation
623
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
623
01:23Rheumatic Heart Disease I: Introduction
27
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
27
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
43
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
43
01:11Genome-wide Association Studies-GWAS
13.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.8K
01:20Rheumatic Heart Disease IV: Nursing Management
30
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
30
01:30Coronary Artery Disease I: Introduction
42
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
42