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Published on: January 16, 2019
Alterations in Serum Concentration of Soluble CD163 within Five Study Days from ICU Admission Are Associated with
Magdalena Mierzchała-Pasierb1, Małgorzata Lipińska-Gediga2, Łukasz Lewandowski1
1Department of Biochemistry and Immunochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Background:
CD163, a cell membrane surface molecule specifically expressed by macrophages with an anti-inflammatory phenotype, participates in innate immunity. The purpose of the study was to evaluate the clinical utility of sCD163 in septic patients in comparison to other parameters associated with infections, mainly PCT, CRP and IL-18.
Methods:
Serum samples were obtained from 40 septic patients on the ICU admission day, 3rd and 5th study days. The control group consisted of 30 healthy volunteers from whom the specimen was collected once. An enzyme-linked immunosorbent assay (ELISA) was used to determine the concentrations of sCD163 and IL-18. CRP and PCT records, among others, were provided by the hospital.
Results:
Septic shock was associated with the highest concentrations of sCD163 and IL-18. Admission values of sCD163 significantly contributed to mortality prediction in septic patients.
Conclusions:
The concentration of sCD163 determined on the ICU admission day may potentially be utilized in estimation of the odds of death among septic patients.
Insights
Soluble CD163 (sCD163), an anti-inflammatory macrophage marker, shows potential in predicting mortality in sepsis patients. Higher sCD163 levels on ICU admission correlate with increased mortality risk, offering clinical utility beyond traditional markers.
Area of Science:
- Immunology
- Critical Care Medicine
- Biomarker Discovery
Background:
- CD163 is a macrophage surface molecule involved in innate immunity.
- Soluble CD163 (sCD163) is a marker of anti-inflammatory macrophages.
- Sepsis is a life-threatening condition requiring accurate prognostic markers.
Purpose of the Study:
- To assess the clinical utility of sCD163 in predicting outcomes for septic patients.
- To compare sCD163 with established infection markers like procalcitonin (PCT), C-reactive protein (CRP), and interleukin-18 (IL-18).
Main Methods:
- Serum samples collected from 40 septic patients on days 1, 3, and 5, and 30 healthy controls.
- Enzyme-linked immunosorbent assay (ELISA) used for sCD163 and IL-18 quantification.
- Hospital records provided CRP and PCT values.
Main Results:
- Septic shock exhibited the highest sCD163 and IL-18 concentrations.
- Admission sCD163 levels significantly predicted mortality in septic patients.
- sCD163 demonstrated potential as a prognostic biomarker.
Conclusions:
- sCD163 levels at ICU admission can help estimate mortality risk in sepsis.
- sCD163 offers a valuable addition to existing sepsis prognostic tools.
- Further research is warranted to integrate sCD163 into clinical practice for sepsis management.
