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Related Experiment Videos

Synapses on dendritic shafts exhibit a perforated postsynaptic density.

Y Geinisman1, F Morrell, L de Toledo-Morrell

  • 1Department of Cell Biology and Anatomy, Northwestern University Medical School, Chicago, IL 60611.

Brain Research
|October 6, 1987
PubMed
Summary
This summary is machine-generated.

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Synapses in the rat dentate gyrus show perforated postsynaptic densities (PSDs). These perforations, previously seen in axospinous synapses, are also present in dendritic shaft synapses, indicating a common structural feature.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Synaptic Plasticity

Background:

  • The structure of postsynaptic densities (PSDs) is crucial for synaptic function.
  • Previous studies indicated perforated PSDs in some synapse types, like axospinous synapses.

Purpose of the Study:

  • To investigate the presence and nature of perforations in postsynaptic densities (PSDs) of dendritic shaft synapses.
  • To determine if PSD perforations are a common feature across different synapse types.

Main Methods:

  • Analysis of serial electron micrographs from the rat dentate gyrus molecular layer.
  • Three-dimensional reconstruction of postsynaptic densities (PSDs) from serial sections.

Main Results:

  • Dendritic shaft synapses exhibit discontinuous postsynaptic density (PSD) profiles.

Related Experiment Videos

  • These discontinuous profiles result from sectioning of PSDs containing 1-3 perforations.
  • Perforated PSDs are observed in both dendritic shaft and axospinous synapses.

    • Conclusions:

    • The presence of perforations in postsynaptic densities (PSDs) is a shared characteristic of subpopulations of different synapse types.
    • This finding suggests a potentially conserved structural motif in synaptic organization.