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Updated: Aug 10, 2025

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
The Problem of Host and Pathogen Genetic Variability for Developing Strategies of Universally Efficacious Vaccination
1Department of Biochemistry, Microbiology and Immunology, Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Abstract:
Rational vaccination against and immunotherapy of any infectious disease requires knowledge of how protective and non-protective immune responses differ, and how immune responses are regulated, so their nature can be controlled. Strong Th1 responses are likely protective against M tuberculosis. Understanding how immune class regulation is achieved is pertinent to both vaccination and treatment. I argue that variables of infection, other than PAMPs, primarily determine the class of immunity generated. The alternative, non-PAMP framework I favour, allows me to propose strategies to achieve efficacious vaccination, transcending host and pathogen genetic variability, to prevent tuberculosis, and personalised protocols to treat disease.
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