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Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
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Molecular Determinants of Chronic Venous Disease: A Comprehensive Review

Davide Costa1,2, Michele Andreucci3, Nicola Ielapi4

  • 1Department of Law, Economics and Sociology, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

International Journal of Molecular Sciences
|February 11, 2023
PubMed

Insights

Chronic Venous Disease (CVD) involves complex genetic and cellular factors affecting leg veins. Understanding these molecular determinants, including extracellular matrix changes, is key to managing this common condition.

Area of Science:

  • Vascular Biology and Medicine

Background:

  • Chronic Venous Disease (CVD) is a prevalent condition affecting lower limb veins, leading to diverse symptoms and significant disability.
  • Its complex etiology involves multifactorial genetic, proteomic, and cellular mechanisms impacting venous structure and function.

Purpose of the Study:

  • To provide an up-to-date overview of the molecular determinants of Chronic Venous Disease.
  • To explore the roles of genetic predisposition, hormonal influences, extracellular matrix imbalance, and endothelial dysfunction in CVD.

Main Methods:

  • This review synthesizes current scientific literature on the molecular underpinnings of CVD.
  • It focuses on genetic expressions, extracellular matrix alterations, and endothelial function.

Main Results:

  • Genetic factors related to angiogenesis and vascular development influence CVD susceptibility.
  • Alterations in the extracellular matrix (ECM) are identifiable and potentially targetable.
  • Endothelial dysfunction plays a significant role in the pathophysiology of CVD.

Conclusions:

  • Molecular determinants, including genetic and ECM factors, are crucial in understanding and potentially treating Chronic Venous Disease.
  • Further research into these molecular pathways can lead to targeted therapeutic strategies for CVD.

Keywords:
chronic venous diseasechronic venous leg ulcersextracellular matrixgeneticshistopathologyvaricose veins

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