Related Experiment Video
Updated: Aug 10, 2025

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
Morphological and Functional Remodeling of Vascular Endothelium in Cardiovascular Diseases
Ghassan Bkaily1, Danielle Jacques1
1Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Abstract:
The vascular endothelium plays a vital role during embryogenesis and aging and is a cell monolayer that lines the blood vessels. The immune system recognizes the endothelium as its own. Therefore, an abnormality of the endothelium exposes the tissues to the immune system and provokes inflammation and vascular diseases such as atherosclerosis. Its secretory role allows it to release vasoconstrictors and vasorelaxants as well as cardio-modulatory factors that maintain the proper functioning of the circulatory system. The sealing of the monolayer provided by adhesion molecules plays an important role in cardiovascular physiology and pathology.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Coronary Artery Disease II: Pathophysiology
Heart Failure II: Pathophysiology
Overview of the Vascular System
Structure of Blood Vessels
Pathophysiology of Heart Failure

