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Mesenchymal Stem Cells and Their Exocytotic Vesicles.
Hao Cai1, Haidong Guo1,2
1Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
International Journal of Molecular Sciences
|February 11, 2023
Summary
Mesenchymal stem cells (MSCs) and their extracellular vesicles show promise in treating various diseases. This review highlights recent research on MSCs and their therapeutic potential in regenerative medicine.
Area of Science:
- Regenerative Medicine
- Cell Biology
- Biomedical Engineering
Background:
- Mesenchymal stem cells (MSCs) possess osteogenic, chondrogenic, and adipocyte differentiation potential.
- MSCs exhibit therapeutic effects including anti-inflammation, immune regulation, and secretion of bioactive factors.
- Extracellular vesicles derived from MSCs mimic the therapeutic functions of MSC transplantation.
Purpose of the Study:
- To review recent research progress on Mesenchymal stem cells (MSCs).
- To summarize the therapeutic applications of MSCs and their extracellular vesicles.
- To highlight the potential of MSC-derived extracellular vesicles in regenerative medicine.
Main Methods:
- Literature review of recent studies on MSCs and their extracellular vesicles.
- Analysis of research on MSC therapeutic functions in various disease models.
- Synthesis of findings on the role of MSC-derived extracellular vesicles.
Main Results:
- MSCs are investigated for orthopedic, geriatric, metabolic diseases, and sports functions.
- MSC therapeutic actions extend to liver, kidney, cardiovascular, and cerebrovascular diseases.
- MSC extracellular vesicles demonstrate comparable therapeutic efficacy to MSC transplantation.
Conclusions:
- MSCs and their extracellular vesicles represent a promising therapeutic strategy.
- Further research into MSC-derived extracellular vesicles can advance regenerative medicine.
- The review underscores the significant potential of MSCs and their exosomes in diverse clinical applications.
Keywords:
cardiocerebral diseasesdifferentiationextracellular vesiclesimmunomodulationmesenchymal stem cellssignaling pathwaysMore Related Videos
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