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Updated: Aug 10, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
CircAMOTL1 RNA and AMOTL1 Protein: Complex Functions of AMOTL1 Gene Products
Joanna Sadlak1,2, Ila Joshi1, Tomasz J Prószyński1
1Laboratory of Synaptogenesis, Łukasiewicz Research Network-PORT Polish Center for Technology Development, Stabłowicka 147, 54-066 Wrocław, Poland.
Abstract:
The complexity of the cellular proteome facilitates the control of a wide range of cellular processes. Non-coding RNAs, including microRNAs and long non-coding RNAs, greatly contribute to the repertoire of tools used by cells to orchestrate various functions. Circular RNAs (circRNAs) constitute a specific class of non-coding RNAs that have recently emerged as a widely generated class of molecules produced from many eukaryotic genes that play essential roles in regulating cellular processes in health and disease. This review summarizes current knowledge about circRNAs and focuses on the functions of AMOTL1 circRNAs and AMOTL1 protein. Both products from the AMOTL1 gene have well-known functions in physiology, cancer, and other disorders. Using AMOTL1 as an example, we illustrate how focusing on both circRNAs and proteins produced from the same gene contributes to a better understanding of gene functions.
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