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Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction.

Wang Li1,2, Xinyu Shu1,2, Xiaoyu Zhang1,2

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Microgravity disrupts liver function by altering the YAP/TAZ pathway, a key regulator of cell mechanics and metabolism. This disruption impacts liver homeostasis during spaceflight.

Keywords:
cytoskeletonliver metabolismmechanosensingmicrogravitynuclear deformationphase separation

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Area of Science:

  • Space biology
  • Hepatology
  • Cellular mechanobiology

Background:

  • Spaceflight-induced microgravity disrupts liver function through complex mechano-biological processes.
  • The YAP/TAZ pathway is a known mechanosensitive pathway crucial for hepatocyte metabolism.
  • The specific role of YAP/TAZ in microgravity-induced liver dysfunction remains unclear.

Purpose of the Study:

  • To discuss liver function alterations caused by microgravity.
  • To summarize the role of the YAP/TAZ pathway in connecting liver metabolism with microgravity.
  • To elucidate the potential mechanisms by which microgravity affects YAP/TAZ signaling.

Main Methods:

  • Review and discussion of existing evidence on microgravity effects on liver function.
  • Analysis of the involvement of YAP/TAZ in mechanotransduction and phase separation.
  • Speculation on mechanisms of YAP/TAZ regulation under microgravity.

Main Results:

  • Microgravity and simulated microgravity alter liver function.
  • YAP/TAZ pathway is implicated as a mediator between microgravity and liver metabolism.
  • Evidence suggests YAP/TAZ target gene expression is influenced by mechanotransduction and phase separation.

Conclusions:

  • Microgravity may dysregulate YAP/TAZ activation through cytoskeletal remodeling or nuclear deformation.
  • Altered diffusion limits in condensates due to microgravity could impact YAP/TAZ.
  • Disruption of these pathways by microgravity likely leads to a breakdown of liver homeostasis.