Related Experiment Video
Updated: Sep 3, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age?
Matteo Puccetti1, Aurelie Schoubben1, Stefano Giovagnoli1
1Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy.
Abstract:
As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19, mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the successful implementation of the systemic delivery of mRNA for safe human consumption. In this manuscript, we provide an overview of current mRNA therapeutic applications and discuss key biological barriers to delivery and recent advances in the development of nonviral systems. The relevant challenges that LNPs face in achieving cost-effective and widespread clinical implementation when delivering mRNA are likewise discussed.
Related Concept Videos
Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Modified-Release Drug Delivery Systems: Overview
Modified-Release Drug Delivery Systems: Bioavailability
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Site-Targeted
Site-Targeted Drug Delivery Systems: Polymeric Carriers

