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Updated: Aug 10, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment
Sara Cruciani1,2, Alessandro Palmerio Delitala3, Maria Laura Cossu4
1Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Abstract:
Obesity is a complex worldwide disease, characterized by an abnormal or excessive fat accumulation. The onset of this pathology is generally linked to a complex network of interactions among genetic and environmental factors, aging, lifestyle, and diets. During adipogenesis, several regulatory mechanisms and transcription factors are involved. As fat cells grow, adipose tissue becomes increasingly large and dysfunctional, losing its endocrine function, secreting pro-inflammatory cytokines, and recruiting infiltrating macrophages. This long-term low-grade systemic inflammation results in insulin resistance in peripheral tissues. In this review we describe the main mechanisms involved in adipogenesis, from a physiological condition to obesity. Current therapeutic strategies for the management of obesity and the related metabolic syndrome are also reported.
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