Related Experiment Video
Updated: Aug 1, 2026
10:38
Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
12.7K
Recent Advances on Surface-Modified GBM Targeted Nanoparticles: Targeting Strategies and Surface Characterization
Francesca Rodà1,2,3, Riccardo Caraffi1,3, Silvia Picciolini2
1Clinical and Experimental Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy.
International Journal of Molecular Sciences
|February 11, 2023
Summary
Nanoparticles offer a promising strategy for glioblastoma multiforme (GBM) treatment by improving drug delivery across the blood-brain barrier (BBB) and targeting tumors. Surface functionalization is key for effective nanoparticle-based GBM therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis.
- Current therapies face challenges in drug delivery across the blood-brain barrier (BBB) and tumor specificity.
Purpose of the Study:
- To review recent advancements in nanoparticle (NP)-based drug delivery strategies for GBM.
- To analyze the role of surface functionalization in enhancing BBB penetration and tumor targeting.
Main Methods:
- Exploration of recent literature on NP strategies for GBM drug delivery.
- Critical analysis of ligand-based approaches for targeting GBM cells and the tumor microenvironment (TME).
Main Results:
- Surface functionalization of NPs is crucial for crossing the BBB and achieving tumor-specific targeting.
- Ligand-based strategies show potential for targeting GBM receptors, pathways, and the TME.
Conclusions:
- Nanoparticles represent a promising avenue for improving GBM treatment efficacy.
- Further development in ligand and surface characterization methods is needed to optimize NP systems for clinical application.
