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Phytochemicals as Immunomodulatory Agents in Melanoma

Claudio Tabolacci1, Daniela De Vita2, Antonio Facchiano3

  • 1Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

International Journal of Molecular Sciences
|February 11, 2023
PubMed

Insights

This review explores plant compounds for melanoma treatment. Phytochemicals show promise in modulating immune responses against melanoma, offering a potentially safer therapeutic avenue.

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • Cutaneous melanoma is a heterogeneous tumor with poor prognosis if diagnosed late.
  • Immunotherapy combined with anti-proliferative strategies shows effectiveness against melanoma growth and metastasis.
  • Plant secondary metabolites are gaining attention as therapeutic agents due to their efficacy and reduced side effects.

Purpose of the Study:

  • To review studies on phytochemicals with demonstrated immunomodulatory activities.
  • To analyze the mechanisms of action of these phytochemicals in melanoma models.
  • To highlight promising plant-derived compounds for melanoma immunotherapy.

Main Methods:

  • Systematic literature search for studies on phytochemicals and melanoma.
  • Inclusion of both in vitro and in vivo investigations.
  • Focus on compounds with proven immunomodulatory effects.

Main Results:

  • Numerous plant secondary metabolites exhibit immunomodulatory properties relevant to melanoma.
  • Evidence supports the application of these phytochemicals in various melanoma models.
  • Phytochemicals demonstrate potential for enhancing anti-melanoma immune responses.

Conclusions:

  • Phytochemicals represent a promising area for developing novel melanoma therapies.
  • Their immunomodulatory effects offer a potential strategy to improve melanoma treatment outcomes.
  • Further research into plant-derived compounds could lead to effective melanoma immunotherapies.
Keywords:
cytokynesimmunomodulationinflammationmelanomaphytochemicalsplant secondary metabolites

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