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The Potential Influence of Advanced Glycation End Products and (s)RAGE in Rheumatic Diseases

Charlotte Delrue1, Reinhart Speeckaert2, Joris R Delanghe3

  • 1Department of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.

International Journal of Molecular Sciences
|February 11, 2023
PubMed

Insights

Advanced glycation end products (AGEs) impact cell function and are linked to rheumatic diseases. Soluble RAGE (sRAGE) acts as a decoy, and its levels may indicate disease progression and cardiovascular risk.

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Advanced glycation end products (AGEs) form from sugar-protein interactions, altering protein structure and activating the receptor for advanced glycation end products (RAGE).
  • RAGE activation contributes to cellular and tissue dysfunction, and is implicated in chronic inflammatory autoimmune disorders like rheumatoid arthritis, lupus, and Sjögren's syndrome.
  • The soluble form of RAGE (sRAGE) acts as a decoy receptor, inhibiting RAGE-mediated pro-inflammatory signaling.

Purpose of the Study:

  • To review the roles of AGEs, sRAGE, and RAGE polymorphisms in rheumatic diseases.
  • To explore the connection between AGE overproduction, atherosclerosis, and disease pathogenesis.
  • To examine the clinical significance of sRAGE levels and RAGE polymorphisms in rheumatic conditions.

Main Methods:

  • Literature review of studies investigating AGEs, RAGE, and sRAGE in rheumatic diseases.
  • Analysis of the biochemical mechanisms of AGEs and RAGE signaling.
  • Examination of the association between RAGE polymorphisms and disease susceptibility.

Main Results:

  • AGE overproduction is linked to rheumatic disease pathogenesis and accelerated atherosclerosis.
  • Low serum sRAGE concentrations correlate with increased cardiovascular risk and poorer prognosis.
  • Certain RAGE polymorphisms may be associated with heightened susceptibility to rheumatic diseases.

Conclusions:

  • AGEs and RAGE play significant roles in the development and progression of rheumatic diseases.
  • sRAGE levels serve as a potential biomarker for disease activity, cardiovascular risk, and prognosis.
  • RAGE polymorphisms represent a potential genetic factor influencing disease susceptibility in rheumatic conditions.
Keywords:
(soluble) receptor of advanced glycation end productsautoimmune inflammatory joint diseasecarboxyethyllysinecarboxymethyllysinecardiovascular riskmethylglyoxalpentosidinepolymorphisms

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