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Updated: Aug 10, 2025

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms
Silvia Salvatori1,2, Irene Marafini1,2, Federica Laudisi1
1Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Abstract:
Gastric cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide. Helicobacter pylori (H. pylori) is one of the main risk factors for this type of neoplasia. Carcinogenetic mechanisms associated with H. pylori are based, on the one hand, on the onset of chronic inflammation and, on the other hand, on bacterial-specific virulence factors that can damage the DNA of gastric epithelial cells and promote genomic instability. Here, we review and discuss the major pathogenetic mechanisms by which H. pylori infection contributes to the onset and development of gastric cancer.
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