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Interactions between Sodium Hyaluronate and β-Cyclodextrin as Seen by Transport Properties.

Lenka Musilová1,2, Aleš Mráček1,2, Eduarda F G Azevedo3

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|February 11, 2023
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This study reveals how beta-cyclodextrins affect sodium hyaluronate diffusion. We found significant interactions, impacting mass transport crucial for drug delivery and food packaging applications.

Keywords:
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Area of Science:

  • Biomaterials Science
  • Physical Chemistry

Background:

  • Hyaluronic acid (HA) and its sodium salt (NaHy) are vital in drug delivery and food packaging.
  • Understanding HA/NaHy mass transport with cyclodextrins is crucial but understudied.
  • Previous research focused on HA functionalization, not cyclodextrin's effect on HA mass transport.

Purpose of the Study:

  • To quantify the effect of beta-cyclodextrins on sodium hyaluronate diffusion.
  • To determine tracer binary and ternary interdiffusion coefficients of NaHy in aqueous beta-cyclodextrin solutions.
  • To elucidate the interaction mechanisms between NaHy and beta-cyclodextrins.

Main Methods:

  • Measurement of tracer binary and ternary interdiffusion coefficients.
  • Analysis of sodium hyaluronate (NaHy) diffusion in water and aqueous beta-cyclodextrin solutions.
  • Investigation of NaHy reduced viscosity dependence on concentration.

Main Results:

  • NaHy diffusion is dependent on its reduced viscosity, showing a minimum at ~2.5 g dm⁻³.
  • A significant decrease (up to 45%) in NaHy limiting diffusion coefficient was observed in the presence of beta-cyclodextrin.
  • This reduction was most pronounced at NaHy concentrations below 1 g dm⁻³.

Conclusions:

  • Sodium hyaluronate (NaHy) exhibits strong interactions with beta-cyclodextrins.
  • These interactions significantly influence NaHy's mass transport properties.
  • Findings are relevant for optimizing HA-based formulations in drug delivery and food science.