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Revisiting the Rotational Field TMS Method for Neurostimulation.

Yiftach Roth1,2, Samuel Zibman1, Gaby S Pell1,2

  • 1Brainsway Ltd., Jerusalem 9777518, Israel.

Journal of Clinical Medicine
|February 11, 2023
PubMed
Summary

Rotational field transcranial magnetic stimulation (rfTMS) activates more neurons than conventional TMS by reducing orientation sensitivity. This novel approach may improve treatment efficacy and consistency for major depressive disorder and other brain conditions.

Keywords:
TMS 360°depolarizationneurostimulationorientational sensitivityrotational fieldtranscranial magnetic stimulation

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Area of Science:

  • Neuroscience
  • Neuromodulation
  • Medical Devices

Background:

  • Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique effective for major depressive disorder (MDD).
  • Conventional TMS has limitations in neuronal activation due to electric field orientation sensitivity, leading to variable clinical outcomes.
  • A greater number of recruited neurons may enhance efficacy and reduce variability in treating neuropsychiatric disorders.

Purpose of the Study:

  • To describe the principles, operation, and potential benefits of rotational field TMS (rfTMS).
  • To highlight rfTMS as a novel method for enhanced neuronal activation compared to conventional TMS.
  • To discuss the potential clinical applications of rfTMS in conditions like MDD and stroke.

Main Methods:

  • Detailed description of the rotational field TMS (rfTMS) method.
  • Explanation of the underlying principles of rfTMS operation.
  • Review of the effects of rfTMS on brain activity and neuronal recruitment.

Main Results:

  • rfTMS enables activation of a larger neuronal population by reducing sensitivity to electric field orientation.
  • The method has the potential to enhance efficacy and reduce outcome variability in clinical applications.
  • Further clinical trials are needed to validate the potential of rfTMS.

Conclusions:

  • Rotational field TMS (rfTMS) represents a significant advancement over conventional TMS by enabling broader neuronal activation.
  • The enhanced recruitment capacity of rfTMS holds promise for improving treatments for major depressive disorder, stroke, and other neuropsychiatric conditions.
  • Validation in clinical trials is essential to confirm the therapeutic benefits of rfTMS.