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A Longer Tpeak-Tend Interval Is Associated with a Higher Risk of Death: A Meta-Analysis

Cathrin Caroline Braun1, Matthias Daniel Zink2, Sophie Gozdowsky3

  • 1Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.

Journal of Clinical Medicine
|February 11, 2023
PubMed

Insights

The T peak-T end interval, a measure on electrocardiograms (ECG), is significantly linked to all-cause mortality. A prolonged interval indicates a higher risk of death, suggesting its potential as a cardiovascular risk stratification tool.

Area of Science:

  • Cardiology
  • Clinical Electrophysiology
  • Preventive Medicine

Background:

  • Establishing noninvasive cardiovascular risk stratification tools remains a clinical challenge.
  • Previous research indicates a prolonged T peak-T end interval may predict mortality.

Purpose of the Study:

  • To systematically evaluate the association between the T peak-T end interval and mortality outcomes.
  • To assess the prognostic value of the T peak-T end interval in cardiovascular risk stratification.

Main Methods:

  • A meta-analysis of observational studies was conducted.
  • Searched Medline (PubMed), Embase, and Cochrane Library from January 2008 to July 2020.
  • Included 29 studies with 23,114 patients assessing T peak-T end interval and all-cause mortality.

Main Results:

  • All-cause deaths were associated with longer T peak-T end intervals (SMD 0.41).
  • Patients with prolonged T peak-T end intervals had a 2.33-fold higher risk of all-cause death.
  • Heart rate correction did not alter the association, but measurement methods showed variability.

Conclusions:

  • The T peak-T end interval is significantly associated with all-cause mortality.
  • The T peak-T end interval shows potential as a noninvasive prognostic marker.
  • Further research is needed to confirm its clinical utility in risk stratification.

Keywords:
Tpeak-Tend intervalall-cause mortalitycardiovascular diseasedispersion of repolarizationrisk stratification

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