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Species correlation in long-term carcinogenicity studies.

J K Haseman1, J E Huff

  • 1National Institute of Environmental Health Sciences, Research Triangle Park, N.C. 27709.

Cancer Letters
|October 30, 1987
PubMed
Summary
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Cancer research in rats and mice shows high concordance. Using male rats and female mice accurately predicts carcinogenicity in 96% of cases, supporting human extrapolation for toxicology studies.

Area of Science:

  • Toxicology
  • Carcinogenicity studies
  • Comparative oncology

Background:

  • Neoplastic response assessment is crucial for chemical safety.
  • Understanding interspecies correlation aids in predicting human health risks.
  • Long-term toxicology and carcinogenicity studies provide extensive data.

Purpose of the Study:

  • To examine species correlation in neoplastic responses across numerous toxicology studies.
  • To evaluate the concordance of carcinogenicity findings between rats and mice.
  • To assess the reliability of using specific sexes (male rats, female mice) for carcinogenicity prediction.

Main Methods:

  • Analysis of 266 long-term toxicology and carcinogenicity studies.
  • Calculation of overall concordance rates between rats and mice.

Related Experiment Videos

  • Assessment of concordance within species (male vs. female).
  • Evaluation of concordance using a subset of male rats and female mice.

    • Main Results:

    • Overall concordance between rats and mice was 74% (198/266).
    • Intraspecies concordance was high: 87% for rats and 89% for mice.
    • Using only male rats and female mice yielded 96% concordance (255/266) for carcinogenicity conclusions.

    Conclusions:

    • High interspecies correlation in carcinogenicity findings between rats and mice.
    • The use of male rats and female mice is a reliable predictor of carcinogenicity.
    • Extrapolation of carcinogenicity outcomes to humans is supported by these findings.