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Enhanced Emulsifying Ability of Deoxycholate through Dynamic Interaction with Layered Double Hydroxide.

Jing Xie1, Kyounghyoun Lee2, Hyeonjin Park1

  • 1Department of Energy and Materials Engineering, Dongguk University, Seoul 04620, Republic of Korea.

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Summary

This study enhanced the emulsifying properties of deoxycholic acid (DCA) by combining it with layered double hydroxide (LDH) nanoparticles. The resulting DCA-LDH hybrid effectively prevents molecular aggregation, leading to highly stable oil-in-water emulsions.

Keywords:
deoxycholic acidemulsifieremulsifying abilityemulsion formulationlayered double hydroxide

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Area of Science:

  • Materials Science
  • Colloid and Surface Chemistry

Background:

  • Deoxycholic acid (DCA) is a natural surfactant with limited emulsifying stability due to molecular aggregation under acidic or imbalanced conditions.
  • Layered double hydroxide (LDH) nanoparticles offer potential for stabilizing surfactant formulations.

Purpose of the Study:

  • To improve the emulsifying ability of deoxycholic acid (DCA) by creating a hybrid with layered double hydroxide (LDH) nanoparticles.
  • To investigate the stability of oil-in-water emulsions formulated with DCA-LDH hybrids under various conditions.

Main Methods:

  • In situ growth of LDH nanoparticles onto DCA molecules to form homogeneous DCA-LDH hybrids.
  • Dynamic light scattering (DLS) to measure micelle size and polydispersity index (PDI).
  • Turbidity monitoring to assess emulsion stability, coalescence, and creaming.

Main Results:

  • The DCA-LDH hybrid successfully prevented DCA molecular aggregation at acidic pH and imbalanced water-to-oil ratios.
  • Emulsions with DCA-LDH maintained small micelle sizes (<500 nm) and low PDI (<0.3) under pH changes and dilution, unlike DCA-only emulsions.
  • DCA-LDH formulations exhibited significantly reduced coalescence and creaming compared to DCA-only formulations.

Conclusions:

  • The dynamic interaction between LDH layers and DCA molecules enhances emulsion stability under challenging conditions.
  • DCA-LDH hybrids represent a promising approach for creating robust and stable oil-in-water emulsions.
  • This synergistic interaction overcomes the inherent limitations of DCA as a surfactant.