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Preparation and Antibacterial Properties of a Composite Fiber Membrane Material Loaded with Cationic Antibacterial
Lin Li1, Chengfu Zhang1, Lina Tian1
1State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nano-Biotechnology, Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, Yanshan University, Qinhuangdao 066004, China.
Abstract:
Microbial infections due to bacteria, viruses, and molds are a serious threat to both human life and the health of other organisms. To develop inexpensive, easy-to-prepare, efficient, and portable nano-antibacterial materials, as well as to explore the antibacterial prospects of cationic antibacterial agents, in this work, six different membrane materials were prepared by the electrostatic spinning method and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR). The materials were tested for antimicrobial properties using a modified AATCC100-200 test method. Under the most suitable spinning conditions, the doping amount of the cationic antimicrobial agent, CTAB, had the greatest influence on the antimicrobial performance. The antimicrobial performance of PCL/PEO/CS/CTAB0.4 was the highest among the prepared materials, with 83.7% effectiveness against S. aureus and 99.9% against E. coli. The antimicrobial performance was found to be stable. In our study, we determined the most suitable spinning ratio to prepare an inexpensive and efficient cationic antimicrobial agent. Biodegradable, high-antimicrobial-activity antimicrobial materials can be applied as films, and this new nanofiber material has shown great potential in wound dressings and as a mask material due to its remarkable antimicrobial efficiency.
Insights
Researchers developed new, inexpensive nano-antibacterial materials using electrostatic spinning. The PCL/PEO/CS/CTAB0.4 material showed high effectiveness against bacteria, demonstrating potential for wound dressings and masks.
Area of Science:
- Materials Science
- Nanotechnology
- Microbiology
Background:
- Microbial infections pose significant threats to human and organism health.
- Development of cost-effective, efficient, and portable nano-antibacterial materials is crucial.
- Cationic antibacterial agents offer promising antimicrobial properties.
Purpose of the Study:
- To prepare and characterize novel nano-antibacterial membrane materials via electrostatic spinning.
- To evaluate the antimicrobial efficacy of these materials against common bacteria.
- To determine the optimal conditions for preparing efficient cationic antimicrobial agents.
Main Methods:
- Electrostatic spinning was used to prepare six different membrane materials.
- Materials were characterized using SEM, TEM, XRD, and FT-IR.
- Antimicrobial properties were assessed using a modified AATCC100-200 test method.
Main Results:
- The doping concentration of CTAB significantly impacted antimicrobial performance.
- PCL/PEO/CS/CTAB0.4 exhibited the highest antimicrobial effectiveness (83.7% against S. aureus, 99.9% against E. coli).
- The prepared nano-antibacterial materials demonstrated stable performance.
Conclusions:
- An inexpensive and efficient cationic antimicrobial agent was successfully prepared.
- The biodegradable nanofiber material shows significant potential for applications in wound dressings and masks.
- This study highlights the efficacy of electrostatic spinning for creating advanced antimicrobial materials.
