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Stimulus-Responsive Ultrathin Films for Bioapplications: A Concise Review.

Maria Benelmekki1, Jeong-Hwan Kim2

  • 1Nanomaterials Lab, College of Engineering, Swansea University, Bay Campus, Fabian Way, Swansea SA1 8EN, UK.

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Summary

Polymer template liquid exfoliation (PTLE) enables the creation of high-performance stimulus-responsive nanosheets (NSHs) and nanoscrolls (NSCs). These nanostructures show promise for advanced applications in biosensing and drug delivery systems.

Keywords:
2D materialshybrid nanosheetsinterfacesnanomedicinenanotechnologystimulus-responsivesurface chemistry

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Nanosheets (NSHs) are ultrathin films (atomic layer to tens of nanometers) with large surface areas and abundant active sites.
  • NSHs from materials like gold, carbon, graphene, and boron nitride are crucial for electronics, optics, membranes, drug delivery, and imaging.
  • Current synthesis methods include top-down exfoliation and bottom-up crystal growth.

Purpose of the Study:

  • To review the synthesis and applications of stimulus-responsive nanosheets and nanoscrolls.
  • To highlight the advantages of polymer template liquid exfoliation (PTLE) for creating high-quality NSHs and composites.
  • To explore the potential of these nanostructures in biosensing and controlled drug release.

Main Methods:

  • Focus on polymer template liquid exfoliation (PTLE) for nanosheet fabrication.
  • Discusses the formation of stimulus-responsive nanosheets through polymer chain growth.
  • Explains the rolling mechanism of nanosheets into nanoscrolls (NSCs) with tunable gaps.

Main Results:

  • PTLE methods yield high-performance, stable hybrid NSHs and composites with tailored properties.
  • Stimulus-responsive NSHs can be synthesized, enabling their transformation into nanoscrolls.
  • Nanoscrolls exhibit tunable interlayer gaps, enhancing their functionality.

Conclusions:

  • PTLE is the most suitable method for producing advanced nanosheets and composites.
  • Stimulus-responsive nanostructures, particularly nanoscrolls, offer significant potential for biosensing and drug delivery.
  • Further advances in PTLE synthesis are expected to drive innovation in nanomedicine and nanotechnology.