Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions

Area of Science:

• Organic Chemistry
• Synthetic Chemistry
• Reaction Mechanisms

Background:

• Radical reactions are crucial for forming carbon-carbon and carbon-heteroatom bonds.
• One-pot cascade reactions offer synthetic and operational efficiency.
• Cyclic compounds with multiple functional groups are valuable in chemistry.

Purpose of the Study:

• To summarize recent advancements in radical addition and cyclization reactions.
• To highlight the synthesis of difunctionalized cyclic compounds.
• To cover diverse substrates including dienes, diynes, enynes, and arene-based compounds.

Main Methods:

• Radical addition and cyclization strategies.
• Utilizing substrates like dienes, diynes, and enynes.
• Employing various initiation methods: radical initiators, transition metal catalysis, photoredox, and electrochemistry.

Main Results:

• Development of efficient one-pot cascade reactions for cyclic skeleton assembly.
• Successful difunctionalization of cyclic compounds.
• Broad applicability across different unsaturated starting materials.

Conclusions:

• One-pot radical cascade reactions provide an efficient route to difunctionalized cyclic compounds.
• The reviewed methods offer versatile strategies for complex molecule synthesis.
• Advancements in radical chemistry enable novel synthetic pathways.