Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cycloaddition Reactions: MO Requirements for Thermal Activation01:16

Cycloaddition Reactions: MO Requirements for Thermal Activation

3.6K
Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
3.6K
Preparation of Epoxides03:00

Preparation of Epoxides

7.9K
Overview
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of...
7.9K
Cycloaddition Reactions: MO Requirements for Photochemical Activation01:12

Cycloaddition Reactions: MO Requirements for Photochemical Activation

2.2K
Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
2.2K
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

2.7K
Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
2.7K
Prochirality02:05

Prochirality

3.9K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.9K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.2K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atomic-Layer Thinning of Bismuth Oxide Confers Antireduction Stability and Tunable Protonation Pathway in CO<sub>2</sub>-to-Formate Electrocatalysis.

ACS nano·2026
Same author

Stabilizing sub-2 nm δ-Bi<sub>2</sub>O<sub>3</sub> via strong lanthanide-oxide-support interaction for durable CO<sub>2</sub> electroreduction to formate.

Nature communications·2026
Same author

Asymmetric Dearomative Dual-Functionalization via Rearomatization-Blocked Sulfonium Claisen Rearrangement.

Angewandte Chemie (International ed. in English)·2026
Same author

Millisecond Aliphatic Iodonium-Claisen Rearrangement Enabling Dual Functionalization of Alkenyl Iodanes.

Angewandte Chemie (International ed. in English)·2026
Same author

Bicarbonate-Dependence for Pd-Catalyzed CO<sub>2</sub> Hydrogenation to Formate over an Electronegativity-Induced Bimetallic Center.

Journal of the American Chemical Society·2025
Same author

Cu(I)-Catalyzed Tetradehydro-Diels-Alder Reaction of Enediynols: Modular Assembly of Multi-substituted Fluorenols.

Organic letters·2025
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Aug 10, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

6.9K

Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection.

Linmeng Fan1, Min Du1, Lichun Kong1

  • 1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China.

Molecules (Basel, Switzerland)
|February 11, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel macrocycle with a backbone allowing for post-synthesis modification of recognition sites. This breakthrough enables tunable molecular recognition properties for advanced applications.

Keywords:
aromatic foldamermacrocyclic moleculepost-synthesis modificationrecognition site variationstructural inspection

More Related Videos

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

447
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.8K

Related Experiment Videos

Last Updated: Aug 10, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

6.9K
Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

447
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.8K

Area of Science:

  • Supramolecular Chemistry
  • Organic Synthesis

Background:

  • Traditional macrocycles have fixed recognition sites, limiting adaptability.
  • Structural backbone variations in macrocycles are challenging to implement.

Purpose of the Study:

  • To design and synthesize a novel oligoamide-based macrocycle.
  • To demonstrate post-synthesis modification for varying recognition sites.
  • To evaluate the structural integrity and molecular recognition capabilities.

Main Methods:

  • Multi-step organic synthesis to produce a parent macrocycle (9).
  • Post-synthesis modification of macrocycle (9) to introduce diverse functional groups (10-13).
  • Nuclear Magnetic Resonance (NMR) spectroscopy (1H NMR, 1H-1H NOESY) for structural elucidation.
  • Preliminary molecular recognition studies.

Main Results:

  • Gram-scale synthesis of the parent macrocycle (9) with a 31% overall yield.
  • Successful introduction of four distinct recognition functional groups (2-methoxyethoxyl, hydroxyl, carboxyl, amide) via post-synthesis modification.
  • NMR studies confirmed the designed macrocyclic structures with internal recognition sites.
  • Macrocycle (10) demonstrated preliminary recognition of n-octyl-β-D-glucopyranoside (14) in chloroform.

Conclusions:

  • A versatile oligoamide-based macrocycle scaffold was successfully developed.
  • Post-synthesis modification offers a flexible strategy for tuning molecular recognition properties.
  • The new macrocycles hold potential for targeted molecular recognition applications.