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Association between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus
Qunyan Xiang1,2, Hui Xu1,2, Junkun Zhan1,2
1Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Background:
Vitamin D deficiency (VDD) increases the risk for type 2 diabetes mellitus (T2DM), which might be related to insulin resistance (IR). We aimed to explore the association between the triglyceride-glucose (TyG) index, a reliable indicator of IR, and VDD in patients with T2DM.
Methods:
There were 1034 participants with T2DM enrolled in the Second Xiangya Hospital of Central South University. The TyG index was calculated as ln (fasting triglyceride (TG, mg/dL) × fasting blood glucose (mg/dL)/2). VDD was defined as 25-hydroxyvitamin D [25(OH)D] level <50 nmol/L.
Results:
Correlation analysis showed a negative association between the TyG index and 25(OH)D level. After adjustments for clinical and laboratory parameters, it was revealed that when taking the Q1 quartile of TyG index as a reference, an increasing trend of VDD prevalence was presented in the other three groups divided by TyG index quartiles, where the OR (95% CI) was 1.708 (1.132-2.576) for Q2, 2.041 (1.315-3.169) for Q3, and 2.543 (1.520-4.253) for Q4 (all p < 0.05).
Conclusions:
Patients with higher TyG index were more likely to have an increased risk of VDD in T2DM population, which may be related to IR.
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