Titanium Dioxide/Chromium Oxide/Graphene Oxide Doped into Cellulose Acetate for Medical Applications

Wound dressings have been designed based on cellulose acetate encapsulated with different concentrations of chromium oxide (Cr₂O₃) and titanium oxide (TiO₂) with/without graphene oxide (GO). This study comprises the structural, morphological, optical, thermal, and biological behavior of chromium oxide/titanium dioxide/graphene oxide-integrated cellulose acetate (CA) films. The CA-based film bond formation was introduced by functional group analysis via Fourier transform infrared (FTIR) spectroscopy. The fabricated Cr₂O₃/TiO₂/GO@CA film SEM micrographs demonstrate transition metal oxides Cr₂O₃ and TiO₂ on a nano-scale. The TiO₂@CA shows the lowest contact angle with 30°. Optically, the refractive index increases from 1.76 for CA to 2.14 for the TiO₂@CA film. Moreover, normal lung cells (A138) growth examination in a function of Cr₂O₃/TiO₂/GO@CA film concentration is conducted, introducing 93.46% with the usage of 4.9 µg/mL. The resulting data showed a promising wound-healing behavior of the CA-based films.