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A Systematic Review on Commercially Available Integrated Systems for Forensic DNA Analysis
Brigitte Bruijns1,2, Jaap Knotter1,2, Roald Tiggelaar3
1Technologies for Criminal Investigations, Saxion University of Applied Sciences, M.H. Tromplaan 28, 7513 AB Enschede, The Netherlands.
Sensors (Basel, Switzerland)
|February 11, 2023
Summary
Commercial rapid DNA analysis systems like ParaDNA, RapidHIT, and ANDE show promise but require improvements in portability, performance, sample versatility, and cost for widespread crime scene use.
Area of Science:
- Forensic Science
- Biotechnology
Background:
- Rapid DNA analysis systems offer potential for expedited forensic investigations.
- Commercial integrated systems (ParaDNA, RapidHIT, ANDE) are emerging for forensic DNA analysis.
Approach:
- This systematic review evaluates three commercial rapid DNA analysis systems.
- Key performance indicators assessed include time-to-result, ease-of-use, portability, and cost per analysis.
Key Points:
- Current systems demonstrate advantages but have limitations for full DNA profiling at crime scenes.
- Areas needing improvement include portability, performance with complex samples, and cartridge costs.
- Enhanced ease-of-use and faster results are crucial for broader adoption.
Conclusions:
- Further development is necessary before rapid DNA systems can be fully implemented for forensic applications.
- Future advancements should focus on improving system capabilities for diverse forensic samples and reducing operational costs.
- Integrated systems that provide both full DNA profiles and indicative analyses would significantly benefit investigations.
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