Related Experiment Videos
Small bowel and plasma gastrin rhythms in cats
J P Accary1, R Salmon, M Dubrasquet
1Inserm U. 10 Recherche en Gastroenterologie, Hopital Bichat, Paris, France.
Chronobiology International
|January 1, 1987
Summary
The gastric antrum is essential for plasma gastrin rhythms in cats. Small bowel resection can restore ultradian gastrin rhythms and alter acid secretion patterns.
Area of Science:
- Gastroenterology
- Chronobiology
- Physiology
Background:
- Plasma gastrin and gastric acid secretion exhibit rhythmic patterns.
- The roles of the gastric antrum and small bowel in these rhythms are not fully understood.
Purpose of the Study:
- To investigate the influence of the gastric antrum and small bowel on plasma gastrin rhythms.
- To examine the impact of antrectomy and small bowel resection on gastric acid and gastrin secretion patterns in cats.
Main Methods:
- Cats with gastric fistulas were used to collect gastric acid and plasma gastrin samples.
- Three groups were studied: controls, antrectomized cats, and cats undergoing small bowel resection.
- Rhythm analysis (circadian and ultradian) was performed on collected data.
Main Results:
- Control cats showed circadian and ultradian rhythms for both acid output and plasma gastrin.
- Antrectomy abolished plasma gastrin rhythms but did not affect acid secretion rhythms.
- Small bowel resection in antrectomized cats restored an ultradian plasma gastrin rhythm and shifted acid secretion acrophase.
Conclusions:
- The gastric antrum plays a critical role in regulating circadian and ultradian plasma gastrin rhythms.
- The small bowel influences plasma gastrin rhythmicity and gastric acid secretion timing.
- These findings highlight the complex interplay between gastric and intestinal segments in regulating digestive hormone rhythms.