Related Experiment Video

Updated: Aug 10, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

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Chemopreventive mechanisms of amentoflavone: recent trends and advancements

Hardeep Singh Tuli1, Hemant Joshi2, Kanupriya Vashishth3

  • 1Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala, Mullana, 133207, India.

Naunyn-Schmiedeberg'S Archives of Pharmacology
|February 11, 2023
PubMed

Insights

Amentoflavone, a natural compound from plants, shows significant anticancer potential by inhibiting tumor growth, promoting cancer cell death, and blocking metastasis. Further research may lead to new cancer treatments.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Oncology

Background:

  • Growing global cancer incidence fuels research into natural anticancer agents.
  • Phytochemicals are increasingly recognized for their preclinical anticancer potential.
  • Amentoflavone, a biflavonoid from plants like Ginkgo, is a compound of interest.

Purpose of the Study:

  • To review the anticancer properties of amentoflavone.
  • To evaluate its potential as a lead compound for novel anticancer drug development.

Main Methods:

  • Literature review of preclinical studies on amentoflavone's anticancer effects.
  • Analysis of its impact on tumor growth, apoptosis, angiogenesis, and metastasis.

Main Results:

  • Amentoflavone demonstrates significant suppression of malignant growth.
  • It induces apoptosis (programmed cell death) in tumor cells.
  • Amentoflavone impedes angiogenesis and metastatic processes.

Conclusions:

  • Amentoflavone exhibits broad-spectrum anticancer activities.
  • It holds promise as a lead compound for developing new anticancer therapeutics.
  • Further in vivo studies and clinical trials are warranted to explore its therapeutic potential, alone or in combination with existing chemotherapeutics.
Keywords:
AmentoflavoneAntiangiogenicAnticancerousAntimetastaticBiflavonoidNanoformulationsSynergistic anticancerous effects

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