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Pelvic nodes ultra-hypo fractionated versus conventionally fractionated IMRT with HDR brachytherapy in prostate cancer: interim analysis of a collaborative multi-institutional non-inferiority phase 3 trial (PCS-XI, NCT05820633).

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Correction to: Redefining the therapeutic landscape of glioblastomas and brain metastasis through cesium brachytherapy and low-kV intra-operative radiation therapy (IORT).

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Robust external-beam calibration of plastic scintillation detectors and uncertainty analysis for<i>in-vivo</i>dosimetry in HDR brachytherapy.

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Generation of 3D reference dosimetric datasets towards adoption of model-based dose calculations for permanent implant prostate brachytherapy.

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Updated: Aug 10, 2025

Author Spotlight: Improving Radiation Therapy Access with Radiation Planning Assistant
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Brachytherapy evolution as seen today.

Luc Beaulieu1,2, Mark J Rivard3

  • 1Centre Intrégé de Cancérologie et Axe oncologie du Centre de recherche du CHU de Québec, CHU de Québec, Québec, Québec, Canada.

Medical Physics
|February 11, 2023
PubMed
Summary
This summary is machine-generated.

Brachytherapy, an established radiation therapy, offers precise dose delivery due to its unique physics, enabling targeted cancer treatment with minimal entrance dose. Its clinical advantages stem from accurate dosimetry and controlled energy application, enhancing tumor targeting and organ sparing.

Keywords:
advancementsbrachytherapydosimetryimage guidancetreatment planning

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Oncology

Background:

  • Brachytherapy is the oldest form of radiation therapy.
  • It presents unique physics and clinical advantages.
  • Advancements in targeting have improved significantly over the last two decades.

Purpose of the Study:

  • To provide an overview of the foundational elements that contribute to brachytherapy's success.
  • To highlight the physics and clinical perspectives of brachytherapy.
  • To emphasize the role of medical physics in brachytherapy development.

Main Methods:

  • The article reviews the physics principles governing brachytherapy dosimetry, including the inverse-square law and dose deposition.
  • Clinical aspects are discussed, focusing on precise energy deposition calculation, dose-outcome relationships, and targeted delivery.
  • The development of targeting capabilities and the contribution of medical physics research are examined.

Main Results:

  • Brachytherapy exhibits an unparalleled dose deposition kernel governed by the inverse-square law, resulting in minimal entrance dose.
  • The modality allows for effective summation of multiple dwell positions and intensity modulation via dwell times.
  • Precise calculation of energy deposition, anticipation of effects, and selective delivery to target volumes while sparing organs at risk are key clinical strengths.

Conclusions:

  • Brachytherapy's unique physics and advanced clinical application make it a successful and evolving radiotherapy modality.
  • The precise targeting and dose control offered by brachytherapy are crucial for effective cancer treatment.
  • Continued research and development in medical physics are vital for the ongoing success and advancement of brachytherapy.