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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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The most common linkers in bioactive molecules and their bioisosteric replacement network

Peter Ertl1, Eva Altmann1, Sophie Racine1

  • 1Global Discovery Chemistry, Novartis Institutes for BioMedical Research, CH-4056 Basel, Switzerland.

Bioorganic & Medicinal Chemistry
|February 11, 2023
PubMed
Summary

This study identifies and analyzes common linkers in bioactive molecules, introducing a novel similarity search method. It provides insights into linker roles, aiding medicinal chemists in drug design and optimization.

Keywords:
Bioisosteric designCheminformaticsHeterocyclesLinkersMedicinal chemistrySubstructure analysis

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