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Updated: Aug 10, 2025
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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Cellular senescence in normal and adverse pregnancy
Blanca Farfán-Labonne1, Philippe Leff-Gelman2, Gabriela Pellón-Díaz2
1Departamento de Fisiología y Desarrollo Celular, Instituto Nacional de Perinatología "Isidro Espinosa de los Reyes", México.
Reproductive Biology
|February 11, 2023
Summary
Cellular senescence (CS) is crucial for healthy pregnancy and labor. Premature CS in maternal-fetal tissues can lead to adverse pregnancy outcomes like preeclampsia and preterm birth.
Area of Science:
- Reproductive biology
- Cellular biology
- Gerontology
Background:
- Cellular senescence (CS) is a state of irreversible cell cycle arrest.
- CS is characterized by specific morphological, phenotypic, and metabolic changes.
- CS has roles in development, tissue repair, aging, and cancer.
Purpose of the Study:
- To discuss cellular senescence and its association with normal pregnancy development.
- To explore the role of CS in adverse pregnancy outcomes.
- To highlight the relevance of CS deregulation in pregnancy pathologies.
Main Methods:
- Literature review and synthesis of current evidence on cellular senescence in pregnancy.
Main Results:
- Cellular senescence is integral to normal pregnancy progression, placentation, and labor onset.
- Premature senescence in maternal-fetal tissues (placenta, membranes, endothelium) is linked to adverse outcomes.
- Adverse outcomes include fetal growth restriction, preeclampsia, preterm birth, and intrauterine fetal death.
Conclusions:
- Cellular senescence plays a critical role in both healthy pregnancy and pathological pregnancy conditions.
- Understanding CS deregulation is key to comprehending and potentially managing pregnancy complications.
Keywords:
Cell agingCell senescenceFetal growth retardationParturitionPlacental circulationPregnancy complicationMore Related Videos
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