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Decreased adreno-cortical suppression utilizing the Nebuhaler for inhalation of steroid aerosols
1Paediatric Department G, University Hospital (Rigshospitalet), Copenhagen, Denmark.
Clinical Allergy
|September 1, 1987
Abstract:
The influence on the adrenocortical function of high-dose topical glucocorticoids inhaled via conventional devices and via a Nebuhaler, was studied in ten children with asthma. In patients treated with dosages of beclomethasone dipropionate or budesonide, in excess of 2100 micrograms/1.73 m2 body surface, the 24-h urinary excretion of free cortisol increased when the inhaler device was changed from a conventional one to a Nebuhaler. This suggests a decreased systemic influence of the inhaled glucocorticoids when these were administered via a Nebuhaler.