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Related Experiment Videos

Bronchial allergen challenge: comparison between two different methods of provocation.

L Frølund1, U G Svendsen, N H Nielsen

  • 1Allergy Unit, Medical Department TTA, State University Hospital, Denmark.

Clinical Allergy
|September 1, 1987
PubMed
Summary

Bronchial allergen challenge results were highly comparable between standard tidal volume breathing and dosimeter methods in asthma patients. This indicates both methods reliably assess airway hyperresponsiveness despite different allergen doses.

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Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology
  • Respiratory Physiology

Background:

  • Asthma is a chronic respiratory disease characterized by airway inflammation and hyperresponsiveness.
  • Bronchial allergen challenge is a key diagnostic tool for assessing asthma severity and triggers.
  • Standard and dosimeter methods exist for allergen inhalation, differing in dose delivery.

Purpose of the Study:

  • To compare the comparability of bronchial allergen challenge results using a standard tidal volume breathing method versus a dosimeter method.
  • To evaluate if different allergen administration methods yield similar assessments of airway hyperresponsiveness in stable asthmatic patients.

Main Methods:

  • Ten stable asthmatic patients underwent bronchial allergen challenge twice.

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  • Allergen was administered via a standard method (tidal volume breathing) or a dosimeter method, with increasing concentrations.
  • Bronchial response was measured by forced expiratory volume in the first second (FEV1) and total respiratory resistance (Rt); late reactions were also recorded.

    • Main Results:

    • High comparability was found between the standard and dosimeter methods for both PC20-FEV1 (r=0.89) and PC40-Rt (r=0.88).
    • No significant differences were observed in the change in FEV1 or Rt, or in the occurrence and magnitude of late asthmatic reactions between the two methods.
    • Despite a 10-fold difference in total allergen doses, the bronchial responses were consistent across methods.

    Conclusions:

    • Bronchial allergen challenge using a standard tidal volume breathing method is highly comparable to using a dosimeter method in stable asthmatic patients.
    • Both methods effectively assess airway hyperresponsiveness and late asthmatic reactions.
    • The dosimeter method offers a more efficient allergen delivery, achieving similar results with lower doses.