Related Experiment Video
Updated: Aug 10, 2025
10:03
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
215
Association of Right Ventricular Functional Parameters With Adverse Cardiopulmonary Outcomes: A Meta-analysis
Alex Ali Sayour1, Márton Tokodi1, Csilla Celeng2
1Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Summary
Three-dimensional echocardiography-derived right ventricular ejection fraction (RVEF) better predicts adverse cardiopulmonary outcomes than conventional measures. This advanced RVEF metric can refine risk stratification for patients with heart and lung conditions.
Area of Science:
- Cardiology
- Pulmonology
- Medical Imaging
Background:
- Right ventricular ejection fraction (RVEF) is crucial for assessing cardiopulmonary health.
- Conventional echocardiographic parameters may not fully capture the prognostic value of right ventricular function.
Approach:
- A meta-analysis was conducted on ten studies involving 1,928 patients.
- Compared the association of unit changes in RVEF, TAPSE, FAC, and FWLS with adverse outcomes.
Key Points:
- A 1 SD reduction in RVEF was strongly linked to adverse outcomes (HR = 2.64).
- Head-to-head comparisons showed RVEF had a significantly stronger association with adverse outcomes than TAPSE, FAC, and FWLS.
Conclusions:
- Three-dimensional echocardiography-derived RVEF demonstrates superior predictive power for adverse clinical outcomes.
- RVEF may enhance risk stratification in patients with cardiopulmonary diseases.
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