A persistent belief in radiopharmaceutical therapy.

Area of Science:

• Medical Physics
• Nuclear Medicine
• Oncology

Background:

• Radiopharmaceutical therapy (RPT) is a targeted cancer treatment delivering cytotoxic radiation.
• The success of RPT relies heavily on precise imaging and radiation dosimetry.
• Advancements in physics are critical for optimizing RPT efficacy and safety.

Purpose of the Study:

• To provide a personal perspective on the evolution of imaging and dosimetry physics in RPT.
• To highlight key contributions and challenges in the field.
• To underscore the importance of physics in the development and application of RPT.

Main Methods:

• This is a review of the author's personal journey and experiences.
• It synthesizes key developments in imaging techniques (e.g., SPECT, PET) and dosimetry methods.
• The review draws upon decades of research and clinical practice in RPT.

Main Results:

• Personal insights into the development of quantitative imaging for RPT.
• Experiences with advancements in internal dosimetry calculations and methodologies.
• Observations on the integration of physics principles into clinical RPT protocols.

Conclusions:

• Continued innovation in imaging and dosimetry physics is vital for the future of RPT.
• Interdisciplinary collaboration is essential for translating physics advancements into clinical practice.
• The author's journey reflects the significant impact of physics on improving cancer patient outcomes with RPT.