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Related Experiment Videos

Influence of exercise on ascorbic acid status in man.

M Gleeson1, J D Robertson, R J Maughan

  • 1Department of Environmental and Occupational Medicine, University Medical School, Aberdeen, Scotland, U.K.

Clinical Science (London, England : 1979)
|November 1, 1987
PubMed
Summary

Endurance running significantly impacts white blood cell counts and ascorbic acid (AA) levels. Plasma AA rises post-exercise but drops below baseline, while lymphocyte AA temporarily increases, suggesting adrenal involvement in exercise-induced AA changes.

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Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Immunology

Background:

  • Understanding the physiological responses to endurance exercise is crucial for athlete health and performance.
  • Ascorbic acid (AA), or vitamin C, plays vital roles in immune function and as an antioxidant.
  • The impact of prolonged strenuous exercise on immune cell dynamics and nutrient levels requires further investigation.

Purpose of the Study:

  • To investigate the changes in circulating leucocytes and ascorbic acid (AA) concentrations in plasma and lymphocytes following a 21 km race.
  • To explore the relationship between plasma AA levels and cortisol concentration during exercise.
  • To determine the time course of recovery for leucocyte counts and AA levels post-exercise.

Main Methods:

  • Nine male participants completed a 21 km race.

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  • Blood samples were collected pre-race, 5 minutes post-race, and at 24 hours, 48 hours, and 72 hours post-race.
  • Measurements included leucocyte counts, differential white blood cell counts, platelet counts, plasma AA concentration, and lymphocyte AA concentration.

    • Main Results:

    • A significant increase in leucocytes, primarily granulocytes, and platelets was observed immediately post-race, returning to baseline within 24 hours.
    • Plasma AA concentration increased significantly post-race, correlating with elevated cortisol levels, but subsequently decreased below pre-exercise levels for at least 48 hours.
    • Lymphocyte AA concentration increased during the race, returning to baseline levels within 48 hours post-race.

    Conclusions:

    • The study indicates a transient leucocytosis and thrombocytosis following prolonged endurance exercise.
    • Plasma AA levels exhibit a complex response, increasing during exercise and then declining significantly, potentially linked to adrenal activity.
    • The adrenal gland may be a primary contributor to ascorbic acid release into circulation during strenuous exercise.