Bioactive constituents from Flacourtia vogelii Hook.f. (Flacourtiaceae)

The chemical investigation of the methanolic root extract of Flacourtia vogelii led to the isolation of a new arylbenzoate derivative, vogelinal (1), together with thirteen known compounds (2-14). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antioxidant, antifungal and antibacterial activities. Compound 7 exhibited the highest antioxidant potential, with RSaof 11.80 ± 2.13 µg/mL, RSaof 42.60 ± 6.32 µg/mL and RC₅₀ of 51.60 ± 7.71 µg/mL for the DPPH, ABTS and FRAP assay, respectively. Compound 13 displayed weak antifungal effect with MIC value of 125 μg/mL against Candida parapsilosis. Compound 8 showed weak antibacterial effect with MIC value of 125 μg/mL, against Shigella dysenteria. The present study, conclude that this species could be a promising source of antioxidant and antibacterial constituents.