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Acquired Reactive Perforating Collagenosis: Case Series
Haritha Kollipara1, Ruttala S Satya2, Gandikota R Rao2
1Department of DVL, GITAM Medical College, Visakhapatnam, Andhra Pradesh, India.
Indian Dermatology Online Journal
|February 13, 2023
Summary
Acquired reactive perforating collagenosis (ARPC) is a rare skin condition. Topical clobetasol propionate and antihistamines effectively treated ARPC lesions in 15 Indian patients, with doxycycline potentially speeding recovery.
Area of Science:
- Dermatology
- Internal Medicine
Background:
- Acquired reactive perforating collagenosis (ARPC) is a rare dermatosis characterized by transepidermal elimination of altered collagen.
- Studies on ARPC, particularly in the Indian population, are scarce, highlighting a need for further clinical research.
Observation:
- Fifteen ARPC patients (10 males, 5 females) were studied, with 13 having comorbid diabetes mellitus.
- Commonly observed lesions included itchy, papular, and nodular eruptions with central keratotic plugs, primarily on limbs and trunk.
- Associated conditions like hypertension, proteinuria, psoriasis, and Koebner's phenomenon were noted in several patients.
Findings:
- Histopathological examination confirmed ARPC in all 15 patients.
- Treatment with topical clobetasol propionate and systemic antihistamines led to lesion regression within 4-6 weeks for all patients.
- Systemic doxycycline appeared to accelerate lesion regression in three patients, though recurrences were noted in six patients within 3 months.
Implications:
- This study provides valuable clinical insights into ARPC presentation and management in India.
- Effective treatment options include topical corticosteroids and antihistamines, with potential benefits from doxycycline.
- The high incidence of comorbidities, especially diabetes, underscores the importance of managing underlying conditions in ARPC patients.
