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Acquired Reactive Perforating Collagenosis: Case Series.

Haritha Kollipara1, Ruttala S Satya2, Gandikota R Rao2

  • 1Department of DVL, GITAM Medical College, Visakhapatnam, Andhra Pradesh, India.

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Summary

Acquired reactive perforating collagenosis (ARPC) is a rare skin condition. Topical clobetasol propionate and antihistamines effectively treated ARPC lesions in 15 Indian patients, with doxycycline potentially speeding recovery.

Keywords:
Acquired reactive perforating collagenosisdiabetesdoxycyclinehistopathologytopical steroid creams

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Area of Science:

  • Dermatology
  • Internal Medicine

Background:

  • Acquired reactive perforating collagenosis (ARPC) is a rare dermatosis characterized by transepidermal elimination of altered collagen.
  • Studies on ARPC, particularly in the Indian population, are scarce, highlighting a need for further clinical research.

Observation:

  • Fifteen ARPC patients (10 males, 5 females) were studied, with 13 having comorbid diabetes mellitus.
  • Commonly observed lesions included itchy, papular, and nodular eruptions with central keratotic plugs, primarily on limbs and trunk.
  • Associated conditions like hypertension, proteinuria, psoriasis, and Koebner's phenomenon were noted in several patients.

Findings:

  • Histopathological examination confirmed ARPC in all 15 patients.
  • Treatment with topical clobetasol propionate and systemic antihistamines led to lesion regression within 4-6 weeks for all patients.
  • Systemic doxycycline appeared to accelerate lesion regression in three patients, though recurrences were noted in six patients within 3 months.

Implications:

  • This study provides valuable clinical insights into ARPC presentation and management in India.
  • Effective treatment options include topical corticosteroids and antihistamines, with potential benefits from doxycycline.
  • The high incidence of comorbidities, especially diabetes, underscores the importance of managing underlying conditions in ARPC patients.