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Related Experiment Video

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Polymeric microcarriers for minimally-invasive cell delivery.

Chunyan Duan1, Mingjia Yu1, Changji Hu1

  • 1School of New Energy and Environmental Protection Engineering, Foshan Polytechnic, Foshan, China.

Frontiers in Bioengineering and Biotechnology
|February 13, 2023
PubMed
Summary

Injectable microscale carriers offer a minimally invasive approach for tissue engineering (TE), improving cell delivery and survival. These advanced biomaterials overcome limitations of traditional scaffolds, promoting tissue regeneration in situ and in vivo.

Keywords:
injectable architecturesmicrofluidic technologyminimally-invasivepolymeric carrierstissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Traditional tissue engineering (TE) uses 3D scaffolds for tissue repair but open surgeries cause inflammation and low cell survival.
  • Injectable microscale carriers present a minimally invasive alternative for delivering cells and growth factors.

Purpose of the Study:

  • To review advancements in microscale cell carriers for tissue engineering.
  • To highlight their design, cell delivery capabilities, and potential for in situ and in vivo tissue regeneration.

Main Methods:

  • Review of biofabrication approaches for creating 3D biomimetic microscale carriers.
  • Analysis of material chemistry and biological aspects of these microcarriers.

Main Results:

  • Microscale carriers demonstrate ease of cell packing and improved cell retention efficacy.
  • These carriers facilitate minimally invasive delivery, reducing inflammatory responses.
  • Evidence of substantial tissue growth in situ and in vivo using these advanced carriers.

Conclusions:

  • Microscale cell carriers represent a significant advancement in tissue engineering, overcoming limitations of conventional scaffolds.
  • Further research into these innovative carriers holds promise for future regenerative medicine applications.