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Shape-memory responses compared between random and aligned electrospun fibrous mats.

Xianliu Wang1, Zhaowenbin Zhang1, Chunping Qin1

  • 1College of Biological Science and Medical Engineering, Donghua University, Shanghai, China.

Frontiers in Bioengineering and Biotechnology
|February 13, 2023
PubMed
Summary

Aligned electrospun fibers exhibit superior shape memory properties compared to random fibers, showing enhanced recovery efficiency and stress. This makes them promising for tissue regeneration applications like regulating stem cell differentiation.

Keywords:
electrospinningmechanoactive scaffoldosteogenic differentiationshape-memory polymerstemperature memory effect

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Tissue Engineering

Background:

  • Smart fibers are crucial for advanced tissue regeneration.
  • Electrospun fibers offer tunable properties but require optimization for shape memory applications.
  • Fiber structure and programming parameters critically influence performance.

Purpose of the Study:

  • To compare shape memory responses between random and aligned electrospun fibers.
  • To investigate the effects of programming temperature and strain on fiber properties.
  • To evaluate the potential of these fibers in regulating stem cell differentiation.

Main Methods:

  • Electrospinning of PLLA-PHBV polymer blend into random and aligned fibrous mats.
  • Systematic variation of programming temperature (37°C, 46°C) and strain (30%, 50%, 100%).
  • Analysis of morphological changes, shape recovery efficiency, switching temperature, and maximum recovery stress.

Main Results:

  • Increasing strain reduced fiber diameter and improved orientation, especially in random fibers.
  • Aligned fibers showed higher shape recovery efficiency and a stronger temperature memory effect.
  • Maximum recovery stress was strain-dependent and significantly higher (2.1-3.4 folds) in aligned fibers.

Conclusions:

  • Aligned electrospun fibers demonstrate superior shape memory performance due to enhanced structural order and molecular orientation.
  • The study highlights the potential of mechanoactive fibrous substrates for controlling stem cell behavior.
  • Optimized aligned smart fibers are promising for advanced tissue regeneration strategies.