Evaluation of the Optimal Position for Vedolizumab in the Japanese Treatment Paradigm for Ulcerative Colitis Using
Akihito Uda1, Yuki Eto1, Yuxin Li2
1Japan Medical Office, Takeda Pharmaceutical Co. Ltd., Tokyo, Japan.
Background:
This analysis assessed the optimal position of vedolizumab for Japanese patients with ulcerative colitis.
Methods:
A Markov model was used to evaluate the performance of 4 treatment algorithms of vedolizumab position: after azathioprine (Algorithm 1); after tacrolimus/cytapheresis (Algorithm 2); after a first anti-tumor necrosis factor alpha (anti-TNFα) (Algorithm 3); and after a second anti-TNFα before colectomy (Algorithm 4).
Results:
Algorithm 1 was the dominant strategy, with an incremental benefit over the other algorithms of 0.028-0.031 quality-adjusted life years.
Conclusions:
This simulation predicts that introducing vedolizumab immediately after a thiopurine and before other therapies will provide most benefit.
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