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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
474
Association Between Psoriasis and Dementia: A Retrospective Cohort Study
Rebecca Zingel1, Louis Jacob2,3, Lee Smith4
1Epidemiology, IQVIA, Frankfurt, Germany.
Journal of Alzheimer'S Disease Reports
|February 13, 2023
Summary
This study found that individuals with psoriasis have a significantly higher risk of developing dementia. The findings highlight a crucial link between psoriasis and increased dementia incidence in Germany.
Area of Science:
- Dermatology
- Neurology
- Epidemiology
Background:
- Psoriasis is a chronic inflammatory disease with potential systemic effects.
- Previous research has not extensively investigated the link between psoriasis and dementia in Germany.
- Understanding this association is crucial for public health initiatives.
Purpose of the Study:
- To determine the association between psoriasis and the risk of all-cause dementia.
- To analyze dementia risk in patients diagnosed with psoriasis within German general practices.
Main Methods:
- Retrospective cohort study using IQVIA Disease Analyzer database (Germany).
- Included 10,583 psoriasis patients and 10,583 matched controls (1:1) from 1995-2014.
- Propensity score matching and Cox regression models analyzed dementia incidence over 15 years.
Main Results:
- Psoriasis patients had a higher cumulative incidence of dementia (22.0% vs. 19.1%).
- The incidence rate of dementia was higher in psoriasis patients (15.0 vs. 11.9 per 1000 person-years).
- Psoriasis significantly increased dementia risk (HR: 1.24; 95% CI: 1.14-1.35).
Conclusions:
- A positive association exists between psoriasis and all-cause dementia in the German population.
- Psoriasis may be a risk factor for dementia development.
- Further research into the mechanisms underlying this association is warranted.
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