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Tween-20-Modified BiVO4 Nanorods for CT Imaging-Guided Radiotherapy of Tumor.
Bo Peng1, Yifan Hao2, Chao Si2
1Department of Oral Radiology, School of Stomatology, China Medical University, Shenyang 110002, P. R. China.
ACS Omega
|February 13, 2023
Summary
This study introduces Tween-20-modified bismuth vanadate nanorods (Tw20-BiVO4 NRs) as effective radiosensitizers for oral cancer. These nanorods enhance radiotherapy by generating free radicals and improving computed tomography imaging for precise treatment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Oral cancer poses a significant health threat, with radiotherapy being a common but limited treatment due to resistance and side effects.
- High atomic number elements like bismuth can enhance X-ray attenuation, improving radiotherapy efficacy.
- Nanomaterials offer potential as radiosensitizers, but biocompatibility and targeted delivery remain challenges.
Purpose of the Study:
- To develop and evaluate novel biocompatible nanomaterials for enhanced and safer oral cancer radiotherapy.
- To investigate the radiosensitizing properties of Tween-20-modified bismuth vanadate nanorods (Tw20-BiVO4 NRs) in oral cancer treatment.
- To explore the potential of Tw20-BiVO4 NRs as contrast agents for computed tomography (CT) imaging-guided radiotherapy.
Main Methods:
- Synthesis of Tween-20-modified BiVO4 nanorods (Tw20-BiVO4 NRs).
- In vitro evaluation of radiosensitization effects on human tongue squamous cell carcinoma cells, including free radical production and chromosome damage.
- In vivo studies using nude mice with subcutaneous tumors, assessing CT imaging capabilities and tumor growth inhibition after radiotherapy.
Main Results:
- Tw20-BiVO4 NRs demonstrated significant radiosensitizing effects, enhancing free radical generation and DNA damage in oral cancer cells.
- The nanorods exhibited strong X-ray absorption, functioning effectively as contrast agents for CT imaging.
- CT imaging-guided radiotherapy using Tw20-BiVO4 NRs significantly inhibited subcutaneous tumor growth in mice.
Conclusions:
- Tw20-BiVO4 NRs are promising radiosensitizers for oral cancer, improving radiotherapy efficacy through enhanced free radical production.
- The dual functionality of Tw20-BiVO4 NRs as radiosensitizers and CT contrast agents enables precise, image-guided cancer therapy.
- This approach offers a new strategy for efficient and safer radiotherapy of oral and maxillofacial cancers.
