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The Three W's of Acetaminophen In Children: Who, Why, and Which Administration Mode

Céline Thibault1,2,3,4, Élaine Pelletier1,4,5, Christina Nguyen4,5

  • 1Department of Pharmacology and Physiology (CT, NK), Université de Montreal, Montreal, QC, Canada.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|February 13, 2023
PubMed

Insights

Acetaminophen is a common children's medication for fever and pain. This report reviews evidence on its administration routes to guide rational clinical use.

Area of Science:

  • Pediatrics
  • Pharmacology
  • Clinical Medicine

Background:

  • Acetaminophen is a widely used medication in pediatric care.
  • Its effectiveness for pain and fever management is established.
  • Evidence on optimal administration routes for children is limited.

Purpose of the Study:

  • To review existing evidence on acetaminophen administration in children.
  • To provide a framework for rational clinical use of acetaminophen.
  • To address the scarcity of knowledge regarding different administration modes.

Main Methods:

  • Literature review of studies on acetaminophen administration in pediatric populations.
  • Synthesis of evidence regarding efficacy and safety of various routes.
  • Development of a clinical guidance framework.

Main Results:

  • Established efficacy of acetaminophen for pediatric fever and pain.
  • Identified gaps in evidence for specific administration routes.
  • Outlined a framework for informed clinical decision-making.

Conclusions:

  • Further research is needed to fully understand optimal acetaminophen administration in children.
  • Clinicians can utilize the provided framework for evidence-based prescribing.
  • Rational use of acetaminophen can be improved with better-supported administration guidelines.

Keywords:
analgesiaantipyreticsfeverinfantpainparacetamolpediatrics

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