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The HUNT study: A population-based cohort for genetic research
Ben M Brumpton1,2,3, Sarah Graham4, Ida Surakka4
1K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Cell Genomics
|February 13, 2023
Summary
The Trøndelag Health Study (HUNT) is a large Norwegian cohort with extensive health and genetic data. This resource enables research into complex diseases and genetic associations over nearly 40 years.
Area of Science:
- Epidemiology
- Genetics
- Public Health
Background:
- The Trøndelag Health Study (HUNT) is a major population-based health study in Norway, initiated in 1984.
- It encompasses approximately 229,000 individuals across four recruitment waves, with genetic data available for about 88,000 participants.
Purpose of the Study:
- To leverage comprehensive health data and genetic information for epidemiological research.
- To investigate the genetic underpinnings of various diseases, including cardiovascular, metabolic, osteoporotic, and liver-related conditions.
Main Methods:
- Population-based cohort recruitment with longitudinal follow-up spanning nearly four decades.
- Collection of detailed health-related behaviors, diagnoses, family history, and physical examination data.
- Integration of genetic data (array genotyping) with extensive electronic health records and national registries.
Main Results:
- Genome-wide association studies (GWAS) have yielded insights into disease mechanisms.
- The cohort facilitates research on a wide range of health outcomes due to comprehensive phenotyping.
Conclusions:
- The HUNT study provides a unique and valuable resource for biomedical research.
- Its extensive longitudinal data, diverse biological samples, and genetic information support advanced studies in disease etiology and prevention.
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