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A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

H₂S-based fluorescent imaging for pathophysiological processes.

Tong-Tong Jia¹, Yuanyuan Zhang², Ji-Ting Hou³

¹College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, China.

Frontiers in Chemistry

|February 13, 2023

Summary

This summary is machine-generated.

Hydrogen sulfide (H₂S) is crucial for physiological processes. New fluorescent probes enable real-time imaging of H₂S, aiding diagnosis of diseases like neurodegenerative disorders and diabetes.

Keywords:

biomarker fluorescence probe hydrogen sulfide pathophysiological processes visualization

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Area of Science:

Biochemistry and Molecular Biology
Medical Imaging
Chemical Sensing

Background:

Hydrogen sulfide (H₂S) is an endogenous signaling molecule vital for numerous physiological functions.
Aberrant H₂S levels are implicated in various pathophysiological conditions, necessitating effective monitoring strategies.
Fluorescence imaging offers real-time observation of analyte concentrations within biological systems.

Purpose of the Study:

To review the design strategies and sensing mechanisms of fluorescent probes for hydrogen sulfide.
To highlight the application of these probes in imaging H₂S dynamics during pathophysiological processes.
To underscore the diagnostic potential of H₂S fluorescent probes in preclinical and clinical settings.

Main Methods:

Literature review focusing on the design and sensing principles of H₂S-specific fluorescent probes.
Analysis of studies employing these probes for imaging H₂S in various disease models.
Synthesis of information on probe performance and application scope.

Main Results:

Detailed overview of diverse H₂S fluorescent probe architectures and their underlying sensing mechanisms.
Demonstration of probe utility in visualizing H₂S changes in neurodegenerative diseases, inflammation, apoptosis, oxidative stress, organ injury, and diabetes.
Evidence supporting the value of H₂S probes in preclinical research.

Conclusions:

Hydrogen sulfide fluorescent probes are powerful tools for investigating H₂S roles in health and disease.
These probes show significant promise for advancing our understanding of H₂S-related pathologies.
The review highlights the potential translation of H₂S fluorescent probes towards clinical diagnostic applications.