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Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
Using publicly available data to identify priority communities for a SARS-CoV-2 testing intervention in a southern
Lynn T Matthews1, Dustin M Long2, Madeline C Pratt1
1Division of Infectious Disease, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Precision population health interventions in rural Alabama identified key factors associated with SARS-CoV-2 positivity. Community engagement and epidemiological data were vital for guiding COVID-19 testing strategies.
Area of Science:
- Public Health
- Epidemiology
- Health Disparities
Background:
- The U.S. Southeast faces a significant burden of SARS-CoV-2 infections and COVID-19.
- Rural Alabama was targeted for a precision population health intervention to enhance SARS-CoV-2 testing.
- The intervention period spanned October 2020 to March 2021.
Approach:
- Utilized public data and community engagement to select counties for intervention.
- Modeled county-level SARS-CoV-2 positivity rates using risk, severity, and mitigation covariates.
- Presented descriptive epidemiologic data to advisory boards for county prioritization.
Key Points:
- In October 2020, no factors correlated with SARS-CoV-2 positivity.
- By March 2021, premature death rates, percent Black residents, preventable hospitalizations, and smoking rates were associated with positivity.
- Counties were ranked by positivity, fatality, case rates, and testing sites.
Conclusions:
- Modeling SARS-CoV-2 proved challenging due to its dynamic nature.
- Epidemiological data facilitated community stakeholder engagement for testing implementation.
- Community involvement in data interpretation is crucial for addressing local diseases.
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